Procoagulant Platelets: Not Just Full of Hot Air Running title: Battinelli; Procoagulant Platelets: Not just full of hot air
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Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen.
The adapter protein SLP-76 is a critical mediator of signal transduction via the platelet collagen receptor glycoprotein VI (GPVI) and its coreceptor FcRgamma. We tested the hypothesis that SLP-76 is required for collagen-induced procoagulant responses in murine platelets. Platelets from SLP-76 null (SLP-76(-/-)) or heterozygous (SLP-76(+/-)) mice were activated with the GPVI agonist convulxin,...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen
The adapter protein SLP-76 is a critical mediator of signal transduction via the platelet collagen receptor glycoprotein VI (GPVI) and its coreceptor FcR . We tested the hypothesis that SLP-76 is required for collagen-induced procoagulant responses in murine platelets. Platelets from SLP-76 null (SLP-76 / ) or heterozygous (SLP-76 / ) mice were activated with the GPVI agonist convulxin, and sur...
متن کاملIntact platelet membranes, not platelet-released microvesicles, support the procoagulant activity of adherent platelets.
The possibility that platelets release microvesicles on adherence to either von Willebrand factor (vWf) or collagen was examined by flow cytometry analysis of the supernatant above layers of adherent platelets. No microvesicle release was detected as a result of adherence to vWf or to collagen, a known platelet agonist. Approximately 8% of the total platelet mass was released as microvesicles a...
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